Having a baby is the most beautiful and happiest dream of all couples. Everyone dreams of creating a new living thing from their own part and witnessing its birth and development. However, sometimes things don't go as planned. Many factors such as genetic factors, disorders or advancing age caused by one of the couples may not allow natural and healthy pregnancies.

Fortunately, nowadays, thanks to advancing medicine, methods such as vaccination, in vitro fertilization and even egg transplantation have become quite common. In this way, thousands-hundreds of thousands of couples have been able to have children. Undoubtedly, every couple wants to have a baby that carries parts of themselves and their spouse. Couples who cannot have this naturally as a result of various factors can fulfill their wishes by placing the embryos fertilized in the laboratory environment into the mother's uterus with vaccination and in vitro fertilization treatment. However, in order for these methods to be used, the ovulation functions of the expectant mother should work at a sufficient level. For expectant mothers who cannot get pregnant with their own eggs, egg transfer (egg donation) is the only sure way.

Egg Donation; It is the process that takes place in the form of placing the embryo in the uterus of the mother by fertilizing the egg cells to be taken from the donor / donor by the in vitro fertilization method, with the sperm taken from the wife of the woman who will be the recipient, in a laboratory environment. These procedures can be applied in our Girne IVF Center in Cyprus.

Who can apply for Egg Donation?

• Those who have applied to in vitro fertilization method before and did not get positive results

• Those who have their ovaries removed for various reasons

• Women who enter menopause at an early age

• Those who want to have children at an older age

The age of the woman is very important in terms of fertility and reproduction. As the age progresses, the chances of a healthy pregnancy decrease. In other words, even if pregnant, there are anomalies such as Down Syndrome or the risk of miscarriage. Egg donation application is almost the same as IVF treatment. However, unlike this treatment, the egg cells are not taken from the expectant mother, but from another donor. The selection of donors is a sensitive issue that requires a lot of attention. Generally, women between the ages of 19-30 and women who have given birth in a healthy way before or who have healthy children as a result of egg donor are preferred. In addition, factors such as blood group, ethnic and physical characteristics and educational status should be suitable for the expectant mother.

After the donor is selected, the donor, recipient and the recipient's spouse are put through a series of tests before the donation process is applied. First of all, the prospective mother is checked by a doctor, and her first evaluation is made by measuring her physical characteristics and some values. Afterwards, blood group, whether it carries AIDS virus (HIV), Hepatitis B and Hepatitis C determinations, blood count, rubella, immunity tests and sugar measurements are made by blood analysis. In order for the recipient to have a healthy pregnancy, whether the uterine cavity is normal or not is checked by hysteroscopy or hysterosalpinography.

At the same time, the donor is also examined by a doctor, the first determinations are made, blood group, blood count, sugar, HIV virus detection and hepatitis B and C measurements are made, such as the tests applied to the recipient mother. In addition, the donor Donor Profile Form undergoes RPR testing for cervical cultures for Ureaplasma and Mycoplasma, for Chlamydia, Gonorrhea and Syphilis. For the husband, semen analysis, blood tests, blood group, Hepatitis B and C tests and AIDS (HIV) test are done.

Before egg donation, the donor's and recipient's menstrual (ovulation) cycles should coincide with birth control pills and similar drugs. On the second or third day of the first menstrual period, while the recipient is getting ready for the intrauterine embryo transfer, the donor should also start the egg-enhancing drugs, and the treatment process, which will last for 10-12 days, begins. On the day the eggs are taken from the donor, the sperm of the father-to-be are collected and subjected to microinjection. Afterwards, similar to IVF treatment, the embryos are transferred to the uterus of the recipient mother within three to five days and waited for 12 days, and a pregnancy test is applied to the expectant mother.

The sperm donation treatment program works like IVF / ICSI treatment. The only difference is that instead of using the male partner sperm sample, you choose a sperm donor to fertilize the eggs. The patient will fill out a patient specification form to help us select the sperm donor that meets your desired specification. Frozen sperm comes from repurposed sperm banks from Europe or the USA.

Sperm Donation

When sperm or insufficient sperm production does not occur in the male patient's testicles, sperm donation is the preferred method for sperm quantity or quality to avoid difficulties in pregnancy or other related health risks. Also, sperm donation is required for women/lesbian couples, single women and women, but the male partner has serious abnormalities in semen parameters.

Among these abnormalities, both obstructive and non-obstructive sperm absence (azoospermia), decreased sperm count (oligospermia), or abnormalities of other sperm or seminal fluid are also indications for donor fertilization. It is also seen when the man has ejaculatory dysfunction or when the woman is RH RH sensitive and the husband is RH positive. Also, couples where the male partner is at risk of passing a genetically inherited disease to the child.

If the desired outcome of a successful pregnancy is not achieved due to insufficient sperm or quality identified as the cause of fertility problems, sperm donation is a possible option to increase the chances of being intentional.

A semen analysis is necessary so that the male patient can analyze the quality, volume and motility of the sperm.

In which cases is sperm donation preferred?

• In case of damage to male patient's testicles due to inflammatory disease

• For single patients with a desire to have children

• In case of incurable sexually transmitted disease in male patients

• In case of hypersensitivity in women due to Rh incompatibility in previous pregnancies

• In cases where the female patient does not have infertility problems, but the male patient has insufficient sperm count or inadequate sperm quality

• In cases of genetic disorders found in sperm

Donor Selection and Screening

You can be offered sperm from the world's largest sperm donation companies as Cryos International Sperm Bank in Denmark and Sperm Bank in Europe. Clinics in Northern Cyprus buy sperm from these companies.

A sperm donor can be matched with desired physical characteristics.

Patients applying for sperm donation are evaluated in detail by the specialist, and the necessary examination of the female patient will be done by a specialist doctor, and then appropriate treatment and tests will be planned.

Pre-Implantation Genetic Testing can be performed on all IVF treatments. When PGD is done we make the 5 main genetic markings of the embryo.

PGD ​​can detect single gene defect disorders that can cause diseases such as:

Muscular Dystrophy,

Sickle cell anemia, cystic fibrosis and Tay-Sachs.

PGS;

trisomy 21,

Down Syndrome,

Trisomy 18 is known as Edwards syndrome.

After these are done with the PGD process, we can transfer a healthy embryo. The process is the same as IVF / ICSI and injections of hormones are administered to help the follicles grow. The PGD process is done after the eggs are retrieved and fertilized with ICSI. The PGD process is done on days 3 and 5 of the progression of embryos. On the 5th or 6th day, healthy embryos are transferred to the treatments of female patients.

Preimplantation Genetic Screening

Preimplantation genetic diagnosis (PGD), also known as Preimplantation Genetic Screening (PGS), is a procedure used to help identify genetic defects in embryos prior to implantation. While the embryo is developing, the PGD procedure prevents certain genetic diseases or disorders from being passed on to the child. Embryos are tested for a panel of chromosomal genetic abnormalities so that only unaffected embryos are implanted back into females, resulting in healthy pregnancy.

PGD ​​was developed as an alternative to prenatal diagnosis and the potential termination of a fetus affected by genetic disease.

How is PGD done?

Preimplantation genetic diagnosis begins with the same process as in vitro fertilization IVF, which includes egg retrieval and fertilization in the laboratory. After the egg retrieval is preformed, the embryos have three to five days to develop, the embryos will divide into multiple cells. First, several cells are microsurgically removed from developing embryos on day 3 or 5, depending on the chromosomes tested by biopsy. In most cases, the chromosome biopsy will be done on day 3 and will be called a cleavage stage biopsy, results will be given on day 4 and we can proceed with the transfer on day 5. embryo transfer day. After PGD identifies embryos without genetic problems, the healthiest embryos are selected and can then be transferred to the uterus.

Who can benefit from PGD?

• Preimplantation genetic diagnosis can benefit any couple at risk of contracting a genetic disease or condition.

• Here is a list of the types of people who may be candidates for PGD:

• History of miscarriages due to genetic disorders

• Repeated IVF mistakes

• Male partners with severe male factor infertility

• An existing child with a genetic disease

• Tissue match required for a sick sibling

• Family history of X-linked disorders

• Chromosomal translocations that can cause implantation failure, recurrent pregnancy loss, mental and physical disorders in children

• Autosomal recessive diseases such as cystic fibrosis, sickle cell anemia, and Tay Sachs disease

• Autosomal dominant diseases including dwarfism and Huntingtn's disease

• Pre-Implantation Genetic Testing can be performed on all IVF treatments. When PGD is done we make the 5 main genetic markings of the embryo.

Yumurta Bağışı

Yumurta bağışı IVF, doğurganlık sorunları olan kadınların çocuk sahibi olma fırsatını yakalar. Yumurta bağışı olan IVF, yumurtaları başarılı bir hamilelik üretmeye uygun olmayan kadınlar için kısırlık tedavisidir. Bazı kadınların yetersiz yumurta üretimi, diğer kadınların kalitesiz yumurta üretimi vardır. Menopoz yaşını aşan ve IVF yumurta bağışı tedavisi için iyi aday olan yaşlı kadınlar. Yumurta bağışı ile IVF uygulanan kadınların çoğu 40 yaşın üzerindedir.

Yumurta donörü ivf prosedürü, ivf tedavisi için bir prosedür gibi gerçekleştirilir, tek fark, genç ve sağlıklı bir kadının yumurtasını kendi yumurtalarınızdan ziyade sağlamasıdır.

Kuzey Kıbrıs'ta Yumurta Bağışı Yasaları

Diğer ülkelerden farklı olarak Kuzey Kıbrıs'ta yumurta bağışı tamamen anonimdir. Kuzey Kıbrıs'ta yumurta bağışı ile gebe kalan her çocuk. Bu yasa aynı zamanda yumurta vericisi ve hedeflenen ebeveyn için de geçerlidir. Her iki taraf da hastaların kimliğini veya yumurtalarını alıp bağışlayan donörü izleyemeyecektir. Verici ve alıcı kimlik bilgileri Kuzey Kıbrıs yasalarına göre kesinlikle gizli olduğundan hem hasta hem de donör kimliği anonim kalacaktır.

Kadınlara Tavsiye Edilen Yumurta Bağışı:

1. Yumurtalıkları yumurta üretmeyen kadınlar

2. Menopoz Öncesi, Menopoz, Cerrahi Olan Kadınlar

3. Yumurtalıkların cerrahi olarak çıkarılması olan kadınlar

4. Yumurtalık bulunmayan kadınlar

5. Kalıtsal genetik koşullardan dolayı

6. Donör Seçimi ve Taraması

Bağışçılar düzenli taramadan geçirilmeli ve doğurganlık ve bulaşıcı hastalık açısından test edilecektir.

Doğru bir donör eşleştirme işlemi için bize aşağıdaki bilgileri vermenizi rica ediyoruz:

1. Sizin ve ortaklarınızın fiziksel özellikleri örneğin: ten renginiz, saç renginiz, göz renginiz

2. Sevgiler ve eşleriniz kan grupları

3. Sevgiler ve ortaklarınız resmi

Tedavinize başlamaya hazır olduğunuzda, bir "verici alıcı formu" doldurmanızı isteyeceğiz. Bu formda, bize kendi fiziksel özelliklerinizin yanı sıra daha fazla donör spesifikasyonu sağlayacaksınız. Bize verdiğiniz bilgilere dayanarak, donör havuzumuzu kriterlerinize uyacak şekilde daraltabileceğiz ve en iyi eşleşen yumurta donörlerimizi kısa listeye alabileceğiz. İlk tarama işlemi tamamlandıktan sonra seçebileceğiniz bir yumurta donörü listesi verilecektir.

Donör seçildikten sonra donör hormon enjeksiyonlarının tedavisine alınacaktır. Yumurtalar alındıktan sonra, yumurta donörünün rolü tamamlanır. Daha sonra erkek hastadan semen örneği toplanır ve oositler vericisi ile ICSI oluşturmak için kullanılır. Embriyolar belli bir aşamada olduktan sonra femal hastanın uterusuna transfer edilirler.